Effects of Indomethacin and Meloxicam, Nonsteroidal Anti-inflammatory Drugs, on Tibia Fracture Union in Rats

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To Cite : Pahlavanhosseini H, Ayati Firoozabadi M, Hassanpour A, Akhavan Tafti M, Abbasi A, et al. Effects of Indomethacin and Meloxicam, Nonsteroidal Anti-inflammatory Drugs, on Tibia Fracture Union in Rats, J Orthop Spine Trauma. 2016 ;2(4):e10701. doi: 10.5812/jost.10701.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Erdogan O, Esen E, Ustun Y, Kurkcu M, Akova T, Gonlusen G, et al. Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: an experimental study in rabbits. J Oral Maxillofac Surg. 2006; 64(2): 180-8[DOI][PubMed]
  • 2. Tsiridis E, Upadhyay N, Giannoudis P. Molecular aspects of fracture healing: which are the important molecules? Injury. 2007; 38 Suppl 1-25[DOI][PubMed]
  • 3. Maddi A, Hai H, Ong ST, Sharp L, Harris M, Meghji S. Long wave ultrasound may enhance bone regeneration by altering OPG/RANKL ratio in human osteoblast-like cells. Bone. 2006; 39(2): 283-8[DOI][PubMed]
  • 4. Reher P, Harris M, Whiteman M, Hai HK, Meghji S. Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts. Bone. 2002; 31(1): 236-41[DOI][PubMed]
  • 5. Karimi Mobarakeh M, Malekpoor Afshar R, Shamsi Meymandi M. Effects of morphine dependency on bone healing in Rat. J Kerman Univ Med Sci. 2004; 11(1): 1-6
  • 6. Massari L, Falez F, Lorusso V, Zanon G, Ciolli L, La Cava F, et al. Can a combination of different risk factors be correlated with leg fracture healing time? J Orthop Traumatol. 2013; 14(1): 51-7[DOI][PubMed]
  • 7. Ikeda K, Takayama T, Suzuki N, Shimada K, Otsuka K, Ito K. Effects of low-intensity pulsed ultrasound on the differentiation of C2C12 cells. Life Sci. 2006; 79(20): 1936-43[DOI][PubMed]
  • 8. Calori GM, Albisetti W, Agus A, Iori S, Tagliabue L. Risk factors contributing to fracture non-unions. Injury. 2007; 38 Suppl 2-8[DOI][PubMed]
  • 9. Gaston MS, Simpson AH. Inhibition of fracture healing. J Bone Joint Surg Br. 2007; 89(12): 1553-60[DOI][PubMed]
  • 10. Bergmann P, Schoutens A. Prostaglandins and bone. Bone. 1995; 16(4): 485-8[DOI][PubMed]
  • 11. Raisz LG. Prostaglandins and bone: physiology and pathophysiology. Osteoarthritis Cartilage. 1999; 7(4): 419-21[DOI][PubMed]
  • 12. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, et al. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003; 21(4): 670-5[DOI][PubMed]
  • 13. Yates JE, Hadi Shah S, Blackwell JC. Clinical inquiries: do NSAIDs impede fracture healing? J Fam Pract. 2011; 60(1): 41-2[PubMed]
  • 14. Dodwell ER, Latorre JG, Parisini E, Zwettler E, Chandra D, Mulpuri K, et al. NSAID exposure and risk of nonunion: a meta-analysis of case-control and cohort studies. Calcif Tissue Int. 2010; 87(3): 193-202[DOI][PubMed]
  • 15. Schmidmaier G, Wildemann B, Melis B, Krummrey G, Einhorn TA, Haas NP, et al. Development and characterization of a standard closed tibial fracture model in the rat. Eur J Trauma. 2004; 30(1): 35-42[DOI]
  • 16. Elmali N, Ertem K, Ozen S, Inan M, Baysal T, Guner G, et al. Fracture healing and bone mass in rats fed on liquid diet containing ethanol. Alcohol Clin Exp Res. 2002; 26(4): 509-13[DOI][PubMed]
  • 17. Hara Y, Nakamura T, Fukuda H, Harada Y, Nezu Y, Tagawa M. Changes of biomechanical characteristics of the bone in experimental tibial osteotomy model in the dog. J Vet Med Sci. 2003; 65(1): 103-7[DOI][PubMed]
  • 18. Kim JC, Crawford Downs J, Azuola ME, Devon Graham H3. Time scale for periosteal readhesion after brow lift. Laryngoscope. 2004; 114(1): 50-5[DOI][PubMed]
  • 19. Liacouras PC, Owen JR, Jiranek WA, Wayne JS. Effect of pigmentation on the mechanical and polymerization characteristics of bone cement. J Arthroplasty. 2006; 21(4): 606-11[DOI][PubMed]
  • 20. Link DP, van den Dolder J, Jurgens WJ, Wolke JG, Jansen JA. Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles. Biomaterials. 2006; 27(28): 4941-7[DOI][PubMed]
  • 21. Rodeo SA, Lebaschi A, Carballo C, Zong J, Khilnani T, Cunningham ME, et al. What's New in Orthopaedic Research. J Bone Joint Surg Am. 2015; 97(23): 1972-8[DOI][PubMed]
  • 22. Allen HL, Wase A, Bear WT. Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand. 1980; 51(4): 595-600[DOI][PubMed]
  • 23. Hogevold HE, Grogaard B, Reikeras O. Effects of short-term treatment with corticosteroids and indomethacin on bone healing. A mechanical study of osteotomies in rats. Acta Orthop Scand. 1992; 63(6): 607-11[DOI][PubMed]
  • 24. Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995; 9(5): 392-400[DOI][PubMed]
  • 25. More RC, Kody MH, Kabo JM, Dorey FJ, Meals RA. The effects of two nonsteroidal antiinflammatory drugs on limb swelling, joint stiffness, and bone torsional strength following fracture in a rabbit model. Clin Orthop Relat Res. 1989; (247): 306-12[DOI][PubMed]
  • 26. Huo MH, Troiano NW, Pelker RR, Gundberg CM, Friedlaender GE. The influence of ibuprofen on fracture repair: biomechanical, biochemical, histologic, and histomorphometric parameters in rats. J Orthop Res. 1991; 9(3): 383-90[DOI][PubMed]
  • 27. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000; 82(5): 655-8[DOI][PubMed]
  • 28. Adolphson P, Abbaszadegan H, Jonsson U, Dalen N, Sjoberg HE, Kalen S. No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial. Arch Orthop Trauma Surg. 1993; 112(3): 127-30[DOI][PubMed]
  • 29. Wheeler P, Batt ME. Do non-steroidal anti-inflammatory drugs adversely affect stress fracture healing? A short review. Br J Sports Med. 2005; 39(2): 65-9[DOI][PubMed]
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